The genome of the fruit fly Drosophila melanogaster was
sequenced in 2000. However, this “completed” sequence
did not include most heterochromatin regions. The
heterochromatin was not sequenced until 2007 (Hoskins
et al. 2007. Science 316:1625–1628). Most completed
genome sequences do not include heterochromatin.
Why is heterochromatin usually not sequenced in
genome projects? (Hint: See Chapter 8 for a more
detailed discussion of heterochromatin.)
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