Answered Essay: A. Given the Chloride reversal potential, V_Ct = -68 mV, will Cl^- ions flow into the cell or out

1. a. Given the Chloride reversal potential, Vr =-68 111, will Cl- ions flow into the cell or out of the cell when V > Vc, where V is the membrane poteial? Will this flux of Cl cause the membrane potential to increase or decrease? Explain b. The concentration o potassium ions inside and outside the cell are about cin = 0.14 M and c ut = 0.005 M, respectively, what is the K+ reversal potential, VR, if kT/e = 25.8 mV, and the ion valence is = 1? e. Unlike the passive Chloride channel, potassium channels have a variable conductance. If the potassium channel is open (gK >0) and V Ve, will ions flow into the cell or out of the cell Will this flux of K+ cause the membrane potential to inerease or decrease? Explain d. For sodium, ions, the ionic concentration is much greater outside the cell than inside,·1, and the reversal potential is Va50 mV. I V Vc, will the opening of the Na channel (gNa >0) cause the membrane potential to increase or decrease? Explain.

A. Given the Chloride reversal potential, V_Ct = -68 mV, will Cl^- ions flow into the cell or out of the cell when V > V_Ct, where V is the membrane potential? Will this flux of Cl^- cause the membrane potential to increase or decrease? Explain. b. The concentration of potassium ions inside and outside the cell are about c_in = 0.14 M and c_out = 0.005 M, respectively, what is the K^+ reversal potential, V_K, if kT/e = 25.8 mV, and the ion valence is z = 1? c. Unlike the passive Chloride channel, potassium channels have a variable conductance. If the potassium channel is open (g_K > 0) and V = V_Ct, will K^+ ions flow into the cell or out of the cell? Will this flux of K^+ cause the membrane potential to increase or decrease? Explain. d. For sodium, ions, the ionic concentration is much greater outside the cell than inside, z = 1, and the reversal potential is V_N almostequalto 50 mV. If V = V_Ct, will the opening of the Na^+ channel (g_Na > 0) cause the membrane potential to increase or decrease? Explain.

Expert Answer

Answer

a) Reversal Potential is the membrane potential where the net flow through any open channels is 0.

VCl = -68 mV is the reversal potential for Chloride

When V > VCl , concentration gradient does not change but electrical gradient will be there. It will be weak inside and hence the net Cl ions will flow out of the cell through any open C channels. Membrane potential will increase with the flux to reach the resting potential so that no net flow could take place and equilibrium between electrical and concentration gradient can be maintained.

b) Cin = 0.14 M

Cout = 0.005 M

kT/e = 25.8 mV and z = 1

Reversal Potential, V_{K}=frac{kT}{ez}lnfrac{[K^{+}]_{outside}}{[K^{+}]_{inside}}

VK = (25.8)ln [0.005/0.14]

VK = -85.971 V

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